Phase II trial of adjuvant pelvic radiation “sandwiched” between ifosfamide or ifosfamide plus cisplatin in women with uterine carcinosarcoma
نویسندگان
چکیده
منابع مشابه
Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study.
PURPOSE To determine if paclitaxel added to ifosfamide as first-line treatment for advanced uterine carcinosarcoma (CS) improves overall survival (OS), progression-free survival (PFS), response, and toxicity. PATIENTS AND METHODS Eligible patients had measurable stage III or IV, persistent, or recurrent uterine CS. Random assignment to treatment was between ifosfamide 2.0 g/m2 intravenously (...
متن کاملChemotherapy for Uterine Carcinosarcoma with Carboplatin, Ifosfamide and Mesna.
BACKGROUND/AIM Uterine carcinosarcomas (UCSs) are highly aggressive, rare, biphasic tumors composed of epithelial and mesenchymal elements. Surgery remains the mainstay of treatment in early-stage disease. Adjuvant pelvic radiotherapy improves locoregional control without proven overall survival (OS) benefit. Although adjuvant ifosfamide-based combination chemotherapy with cisplatin or paclitax...
متن کاملPhase II Study of Vinorelbine Plus Ifosfamide in Patients with Taxane-resistant Metastatic Breast Cancer
than that for cyclophosphamide. There have been several Purpose: The patients with metastatic breast cancer are routinely exposed to taxane and anthracycline as neoadjuvant, adjuvant, and palliative chemotherapeutic agents. This study was designed to evaluate the efficacy and safety of using a vinorelbine and ifosfamide (VI) combination treatment in patients with taxane-resistant metastatic bre...
متن کاملNon-pegylated liposomal doxorubicin plus ifosfamide in metastatic soft tissue sarcoma: results from a phase-II trial.
BACKGROUND/AIM Non-pegylated liposomal doxorubicin (NPLD) has demonstrated antitumour activity equivalent to conventional doxorubicin and a significantly lower risk of cardiotoxicity. This phase II trial was performed to evaluate the activity and the safety of NPLD and ifosfamide combination in patients with metastatic soft tissue sarcoma. PATIENTS AND METHODS Thirty-four patients received NP...
متن کاملUterine Carcinosarcoma after Pelvic Radiotherapy
Radiation is a treatment of many gynecologic malignancies, especially locally-advanced cervical cancer. Development of second malignancies is a rare complication of radiotherapy. Our patient had uterine carsinosarcoma20 years after radiotherapy for cervical cancer. Two theories of radiationinduced malignancies were described: direct damage of double strand DNA and the abscopal or indirect damag...
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ژورنال
عنوان ژورنال: Gynecologic Oncology
سال: 2012
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2011.10.008